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Steps of DNA Replication
This page summarizes the process of DNA replication in eukaryotic cells, by dividing it into simpler steps.
Note: You may click on some parts of the images to get a better description.
Step 5
1) In the lagging strand the DNA Polymerase I “reads” the newly formed fragments by DNA Polymerase III and removes the existing RNA Primers. The gaps are closed by the addition of complementary nucleotides.
Step 6
1) DNA Ligase follows DNA Polymerase I, and joins the Okazaki fragments into one strand by adding phosphates in the remaining – phosphodiester bonds.
2) DNA Polymerase reaches to an end of the strands. When the last RNA primer is removed, it is not possible for the DNA Polymerase I to seal the gap. Therefore, the end of the original strand where the last primer binds is not replicated. These ends consist of non-coding DNA that contains repeated sequences which are called telomeres.
3) Exonuclease searches the replicated strands for any errors and fixes them by replacing the wrong nucleotides. A part of the telomeres is removed as well.
Step 7
1) DNA replication is completed, and a newly formed strand can now be used as the genetic material for a new cell which is created by mitosis.
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